A retrospective observation of virologically suppressed people living with HIV by comparing switching to BIC/TAF/FTC with initial use BIC/TAF/FTC

Abstract

Background

The objective of this study was to observe retrospectively the clinical response of virologically suppressed people living with HIV (PLWH) by comparing switching to BIC/TAF/FTC with initial use BIC/TAF/FTC.

Methods

PLWH using BIC/TAF/FTC was divided into ‘initial use’ group and ‘switching to’ group. Immune response, metabolic parameters and renal function between the two groups were analysed.

Results

The CD4 cell counts was higher in post- treatment than pre- treatment in the ‘switching to’ group (416.54 ± 212.11 cells/mm³ vs. 243.72 ± 156.64 cells/mm³, p < .001); however, significant differences were not observed in the ‘initial use’ group (p = .658). The effect of BIC/TAF/FTC on metabolism was not obvious. Serum creatinine (SCr) was improved in post-treatment than in pre-treatment in ‘switching to’ group (69.03 ± 18.78 vs. 77.52 ± 20.18, p < .001). Platelet count was lower in post-treatment than pre-treatment both in the ‘initial use’ group (175.81 ± 69.27 vs. 202.90 ± 66.56, p = .070) and in the ‘switching to’ group (177.04 ± 64.48 vs. 212.53 ± 63.43, p < .001).

Conclusions

‘Switching to’ is superior to ‘initial use’ BIC/TAF/FTC in immune response among PLWH. The effect of BIC/TAF/FTC on metabolism is not obvious. BIC/TAF/FTC related thrombocytopenia needs to be further explored.

Keywords:

• BIC/TAF/FTC
• clinical response
• initial use
• people living with HIV
• switching to

Acknowledgments

The authors express their thanks to the ‘Editage’ for their assistance in modifying the language in this manuscript.

Ethics approval

The study was approved by the Clinical Research Ethics Committee of the People’s Hospital of Yubei District of Chongqing City (Chongqing, China) (Grant no.: 2023GRKHIV1212).

Consent form

Appropriate informed consent was obtained from patients or their legal surrogates before data collection. All authors approved the final version of the manuscript and consented for publication.

Author contributions

Jian Xu contributed to the conception of the thread. Xianghua Dai and Li Huang collected the data. Yuzhi Shi drafted the manuscript. All authors approved the final version of the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The original data in this study can be obtained from the corresponding author upon reasonable request.

Additional information

Funding

Not applicable.