Changes in sympathetic nervous system activity after renal denervation: results from the randomised Oslo RDN study

Abstract

Purpose

Sympathetic nervous system (SNS) over-activity is associated with essential hypertension. Renal sympathetic denervation (RDN) possibly lowers office- and ambulatory blood pressure (BP) in patients with treatment-resistant hypertension (TRH). We aimed to assess the effect of RDN compared to drug adjustment on SNS activity among patients with TRH by measuring plasma catecholamines and heart rate variability (HRV) during stress tests.

Materials and methods

Patients with TRH were randomised to RDN (n = 9) or Drug Adjustment (DA) (n = 10). We measured continuous HRV and beat-to-beat-BP using FinaPres® and obtained plasma catecholamines during standardised orthostatic- and cold-pressor stress tests (CPT) before- and six months after randomisation.

Results

CPT revealed no differences between groups at baseline in peak adrenaline concentration (69.3 pg/mL in the DA group vs. 70.0 pg/mL in the RDN group, p = 0.38) or adrenaline reactivity (Δ23.1 pg/mL in the DA group vs. Δ29.3 pg/mL in the RDN group, p = 0.40). After six months, adrenaline concentrations were statistically different between groups after one minute (66.9 pg/mL in the DA group vs. 55.3 pg/mL in the RDN group, p = 0.03), and six minutes (62.4 pg/mL in the DA group vs. 50.1 pg/mL in the RDN group, p = 0.03). There was a tendency of reduction in adrenaline reactivity after six months in the RDN group (Δ26.3 pg/mL at baseline vs. Δ12.8 pg/ml after six months, p = 0.08), while it increased in the DA group (Δ13.6 pg/mL at baseline vs. Δ19.9 pg/mL after six months, p = 0.53). We also found a difference in the Low Frequency band at baseline following the CPT (667µs² in the DA group vs. 1628µs² in the RDN group, p = 0.03) with a clear tendency of reduction in the RDN group to 743µs² after six months (p = 0.07), compared to no change in the DA group (1052µs^2, p = 0.39).

Conclusion

Our data suggest that RDN reduces SNS activity after six months. This finding warrants investigation in a larger study. Clinical Trial Number registered at www.clinicaltrials.gov: NCT01673516

Keywords:

• Treatment-resistant hypertension
• Renal denervation
• Catecholamines
• Stress tests
• Sympathetic nervous system

Acknowledgements

The authors would like to thank MSc. Ulla Hjørnholm at the Section for Cardiovascular and Renal Research, Oslo University Hospital Ullevål, Oslo, Norway for her invaluable contribution to this work.

This sub-study was made possible by a public PhD grant from Helse Sør-Øst (South-Eastern Norway Regional Health Authority).

Disclosure statement

The authors report no relevant conflicts of interest.