Relationship between disease and disease severity and semaphorin 5A and hemogram level in obsessive–compulsive disorder

Abstract

Objective

Semaphorin 5A (SEMA 5A) is a neuroprotein that regulates the formation of excitatory synapses between neurons, important in autoimmunity, inflammatory processes and behaviors. This study aimed to investigate the SEMA 5A levels in patients with obsessive–compulsive disorder (OCD) diagnosed for the first time and evaluate the relationship of disease and disease severity with the blood SEMA 5A level and hemogram.

Methods

More than 41,465 patients who applied to the psychiatry clinic from January 2018 to December 2020 were evaluated according to the DSM-5 criteria; 57 patients diagnosed with OCD for the first time, who met the inclusion criteria, were included in the study. Disease severity was investigated administering the Yale Brown Obsessive Compulsion Scale. The peripheral blood SEMA 5A level and hemogram were measured and evaluated in relation to platelet (PLT) activity, neutrophil–lymphocyte ratio (NLR), PLT–lymphocyte ratio (PLR), monocyte–lymphocyte ratio (MLR), C-reactive protein (CRP), and compared with control group of 26 people.

Results

The comparison of the groups revealed a significant difference in SEMA 5A and CRP level, neutrophil count and percentage, lymphocyte count, PLT activity. A significant correlation was found between disease and SEMA 5A level, NLR, PLR, and PLT parameters in diagnosis of OCD. As the severity of OCD increased, the SEMA 5A level and PLT count decreased, while the PDW and MLR values increased.

Conclusion

In patients with OCD, a relationship was found between plasma SEMA 5A, PLT activity, NLR, PLR, and MLR activity levels with disease and the disease severity.

Keywords:

• Blood
• etiology
• obsessive–compulsive disorder
• semaphorin 5A

Disclosure statement

There is no any potential conflicts of interest of each author.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Notes on contributors

Kader Semra Karatas

Kader Semra Karatas has researches on evidence-based psychiatry, bipolar disorder, sleep disorders and obsessive-compulsive disorders. Author, who is both a psychiatrist and a forensic medicine specialist, has been working as an assistant professor at Recep Tayyip Erdoğan University, Medical School, Psychiatry Department since 2015.

Ilkay Bahceci

Ilkay Bahceci, who is a microbiologist, has been working as an assistant at Recep Tayyip Erdoğan University, Medical School, Microbiology Department, since 2016.

Tahsin Gokhan Telatar

Tahsin Gokhan Telatar, who is a public health specialist, has been working as an assistant professor at Recep Tayyip Erdoğan University, Medical School, Public Health Science, since 2018.

Bulent Bahceci

Bulent Bahceci, who is a psychiatrist, has been working as an associate professor at Recep Tayyip Erdoğan University, Medical School, Psychiatry Department, since 2016. He has researches on depressive disorder, suicide and obsessive-compulsive disorders.

Cicek Hocaoglu

Cicek Hocaoglu, who is a psychiatrist, has been working as the head of the department of psychiatry at Recep Tayyip Erdoğan University, Medical School, since 2009. She has many researches on psychiatry, especially suicide.