More Than Structural Cells, Fibroblasts Create and Orchestrate the Tumor Microenvironment

Carolyn J. Baglole Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry,; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry,

Denise M. Ray Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry,; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry,

Steven H. Bernstein Lymphoma Biology Program, James P. Wilmot Cancer Center, Rochester, New York, USA

Steven E. Feldon Department of Ophthalmology, University of Rochester School of Medicine and Dentistry,

Terry J. Smith Division of Molecular Medicine, Harbor-UCLA Medical Center, Torrance, California, USA

Patricia J. Sime Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry,; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry,; Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry,

Richard P. Phipps Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry,; Department of Ophthalmology, University of Rochester School of Medicine and Dentistry,; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry,; Lymphoma Biology Program, James P. Wilmot Cancer Center, Rochester, New York, USACorrespondence[email protected]

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Abstract

The tumor microenvironment comprises many cell types including infiltrating immune cells such as lymphocytes, endothelial cells and a complex stroma consisting mainly of fibroblasts. Fibroblasts are heterogeneous and consist of Thy-1⁺ and Thy-1⁻ subsets that define different biosynthetic and differentiation potential. They produce mediators linked to carcinogenesis and metastasis, including Cox-2 and PGE₂, both of which are also increased in most cancers. This review will highlight the emerging role of the complex fibroblastic stroma in establishing a microenvironment supporting malignant transformation, tumor growth and attenuation of host anti-tumor immune responses.

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More Than Structural Cells, Fibroblasts Create and Orchestrate the Tumor Microenvironment

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More Than Structural Cells, Fibroblasts Create and Orchestrate the Tumor Microenvironment

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