MHC-Restricted Presentation of a Single Repeat of MUC1 Mucin

Melody K. Orr Departments of Internal Medicine and Women's Health and Research Institute, Texas Tech University Health Sciences Center, Amarillo, Texas, USA

Janet S. Burnside Departments of Internal Medicine and Women's Health and Research Institute, Texas Tech University Health Sciences Center, Amarillo, Texas, USA

Catherine A. Phillips Departments of Internal Medicine and Women's Health and Research Institute, Texas Tech University Health Sciences Center, Amarillo, Texas, USA; Cell Biology and Biochemistry; Microbiology and Immunology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA; Veterans Affairs Medical Center, Amarillo, Texas, USA

Ramila Philip Departments of Molecular Biology and Cancer Biology, RPR GenCell, Inc. (formerly Applied Immune Sciences, Inc., (AIS)), Santa Clara, California, USA

Kenneth E. Dombrowski Departments of Internal Medicine and Women's Health and Research Institute, Texas Tech University Health Sciences Center, Amarillo, Texas, USA; Veterans Affairs Medical Center, Amarillo, Texas, USA; Department of Veterans Affairs and the Atlanta Research and Education Foundation, Decateur, Georgia, USA; Departments of Microbiology/Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

Stephen E. Wright Departments of Internal Medicine and Women's Health and Research Institute, Texas Tech University Health Sciences Center, Amarillo, Texas, USA; Cell Biology and Biochemistry; Microbiology and Immunology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA; Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, USA; Veterans Affairs Medical Center, Amarillo, Texas, USACorrespondence[email protected]

Abstract

Major histocompatibility complex (MHC) restriction of antigen presentation of a single mucin1 (MUC1) variable number of tandem repeats peptide (VNTR1) was examined by generating cytotoxic T lymphocytes (CTL) derived from peripheral blood mononuclear cells (PBMC) stimulated with a single repeat MUC1 peptide presented by allogeneic (MHC-independent) or autologous (MHC-dependent) Epstein-Barr Virus (EBV) immortalized B lymphocytes. The ability to generate greater CTL activity against MUC1-expressing tumor cells by stimulation with autologous versus allogeneic EBV-B supports the hypothesis that presentation of a single repeat of MUC1 peptide is MHC-restricted (MHC-dependent).

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MHC-Restricted Presentation of a Single Repeat of MUC1 Mucin

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MHC-Restricted Presentation of a Single Repeat of MUC1 Mucin

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