Differences in Cytokine Production during Aging and Its Relationship with Antimicrobial Peptides Production

ABSTRACT

Aging is a major health issue due to the increased susceptibility of elderly people to infectious, autoimmune, and cardiovascular diseases. Innate immunity is an important mechanism to avoid primary infections; therefore, decreasing of its activity may lead to development of infections. Antimicrobial peptides (AMPs) are effector molecules of innate immunity that can eliminate microbial invaders. The role that cytokines play in the regulation of these innate immune mechanisms needs to be explored. Serum determinations of Th1, Th2, and Th17 cytokines were performed in order to evaluate their association with AMPs human beta-defensin (HBD)-2 and LL-37 in young adults, elder adults, and elder adults with recurrent infections. Our results showed differences in interleukin (IL)-10 and IL-6 among the different groups. Inverse correlations in serum cytokine levels and HBD-2 production were identified for IL-10, IL-2, IL-4, tumor necrosis factor-α, and IL-6. Also inverse correlations were identified for IL-10, IL-4, and cathelicidin (LL-37). Such results could impact the development of immunomodulators that promote AMP production to prevent and/or contain infectious diseases in this population.

KEYWORDS:

• Aging
• cytokines
• defensins
• elderly
• immunosenescence

Acknowledgments

We thank Eliza J. Smithson for her outstanding and priceless help in reviewing and correction of the manuscript. JECD would like to thank “ISSSTE senior association” for their enthusiastic participation in the study. We thank the laboratory staff at the “Emilio Varela Lujan” hospital of Zacatecas, IMSS. BR-S and JAEM are scholars of Fundacion IMSS, Mexico.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Funding

This work was supported by the National Council of Science and Technology in Mexico-CONACyT (FOSSIS-2011-1-161735).

Additional information

Funding

This work was supported by the National Council of Science and Technology in Mexico-CONACyT (FOSSIS-2011-1-161735).