ABSTRACT
Historically, volatile anesthetics have demonstrated interesting interactions with both the innate and adaptive immune systems. This review organizes these interactions into four phases: recognition, recruitment, response, and resolution. These phases represent a range of proinflammatory, inflammatory, and innate and adaptive immune regulatory responses. The interaction between volatile anesthetics and the immune system is discussed in the context of pathogenesis of infectious disease.
Funding
Siavash Sedghi and Hilliard Kutscher were supported by the NIH Ruth L. Kirschestein National Research Service Award Institutional Research Training Grant T32 GM099607.