ABSTRACT
Purpose
This study aimed to evaluate macular perfusion using optical coherence tomography angiography (OCTA) in patients with cone dystrophy and to determine the associations between the quantitative data of OCTA and functional parameters.
Methods
The data of 36 eyes of 18 patients with cone dystrophy and 38 eyes of 19 healthy controls were analyzed. The superficial and deep capillary plexus (SCP and DCP) vessel densities (VD) of the macula, the foveal avascular zone (FAZ) and choriocapillary flow density values were obtained using OCTA. The associations between visual acuity (VA) and full-field electroretinography (ffERG) and the quantitative data of OCTA, and the associations between OCTA and ffERG were analyzed.
Results
: VD was significantly lower in all areas except the foveal area in SCP in the cone dystrophy group compared to the control group. VA was found to be associated with the VDs of the SCP and DCP except for that of the foveal SCP. VA was also associated with dark-adapted, light-adapted wave amplitudes.
Conclusion
OCTA quantitatively showed that macular perfusion was decreased in cone dystrophy compared to the healthy controls. In addition, there was an association between VA and ffERG parameters and quantitative data of OCTA.
Brief Summary
Optical coherence tomography angiography (OCTA) quantitatively showed that macular perfusion was decreased in cone dystrophy compared to the healthy controls. In addition, there was an association between visual acuity and full-field electroretinography parameters and quantitative data of OCTA.
Declaration of Conflicting Interests
The author(s) declare no potential conflict of interest with respect to the research, authorship, and/or publication of this article.
Declaration of Patient Consent
The authors declare that they obtained all appropriate patient consent forms. The patients provided consent for the publication of their clinical information and images in the journal. They were informed that their names and initials would not be revealed.
Disclosure Statement
No potential conflict of interest was reported by the author(s).