ROLES OF IFN-γ ON STAGE CONVERSION OF AN OBLIGATE INTRACELLULAR PROTOZOAN PARASITE, Toxoplasma Gondii

AKIHIKO YANO Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan

HYE-SEONG MUN Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan

MEI CHIN Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan

KAZUMI NOROSE Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan

KAZUYUKI HATA Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan

MASASHI KOBAYASHI Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan

FUMEI AOSAI Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan

YOICHIRO IWAKURA Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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Abstract

IFN-γ downregulates the stage conversion of Toxoplasma gondii (T. gondii), from bradyzoites to tachyzoites, and the expression of heat shock protein 70 (HSP70) of T. gondii ( T.g. HSP70) by tachyzoites. T.g. HSP70 has been shown to downregulate NO release from macrophages and also to induce auto-HSP70 antibody formation and IL-10 secretion by VH11-JH1 B-1 cells, resulting in the suppression of host defense responses to T. gondii infection. A novel category of virulent tachyzoite stage of T. gondii expressing T.g. HSP70 (virulent tachyzoite), which indirectly manifests its pathogenicity by downregulating host defense responses, has been proposed.

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ROLES OF IFN-γ ON STAGE CONVERSION OF AN OBLIGATE INTRACELLULAR PROTOZOAN PARASITE, Toxoplasma Gondii

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ROLES OF IFN-γ ON STAGE CONVERSION OF AN OBLIGATE INTRACELLULAR PROTOZOAN PARASITE, Toxoplasma Gondii

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