Ex Vivo Programming of Antigen-Presenting B Lymphocytes: Considerations on DNA Uptake and Cell Activation

Matthew Wheeler The Department of Medicine and Cancer Center and Biomedical Science Program, University of California, San Diego, La Jolla, California, USA

Xotchil Cortez-Gonzalez The Department of Medicine and Cancer Center and Biomedical Science Program, University of California, San Diego, La Jolla, California, USA

Raffaele Frazzi The Department of Medicine and Cancer Center and Biomedical Science Program, University of California, San Diego, La Jolla, California, USA

Maurizio Zanetti The Department of Medicine and Cancer Center and Biomedical Science Program, University of California, San Diego, La Jolla, California, USACorrespondence[email protected]

Abstract

Plasmids used in DNA vaccination not only serve as a source of antigen, but also have an important adjuvant effect. This review focuses on recent advancements made in understanding how cells internalize DNA, and how internalized DNA activates immune response pathways. We also comment on the role of B cells in both of these processes.

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Ex Vivo Programming of Antigen-Presenting B Lymphocytes: Considerations on DNA Uptake and Cell Activation

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Ex Vivo Programming of Antigen-Presenting B Lymphocytes: Considerations on DNA Uptake and Cell Activation

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