MicroRNA mediated regulation of immunity against gram-negative bacteria

ABSTRACT

Evidence over the last couple decades has comprehensively established that short, highly conserved, non-coding RNA species called microRNA (miRNA) exhibit the ability to regulate expression and function of host genes at the messenger RNA (mRNA) level. MicroRNAs play key regulatory roles in immune cell development, differentiation, and protective function. Intrinsic host immune response to invading pathogens rely on intricate orchestrated events in the development of innate and adaptive arms of immunity. We discuss the involvement of miRNAs in regulating these processes against gram negative pathogens in this review.

KEYWORDS:

• Bacteria
• gram negative
• host immunity
• microRNAs

Disclosure

The authors declare that they have no competing interests.

Acknowledgements

This work was supported by National Institutes of Health Grant (1RO3AI11771401A1), Army Research Office, Department of Defense Contract No. W911NF-11-1-0136 to BPA and National Institute of Child Health and Human Development Grant (HD061580) to LKC.