The role of pro-inflammatory cytokines in lipid metabolism of metabolic diseases

Abstract

Adipose tissue has been considered as a crucial source of certain pro-inflammatory cytokines; conversely, these pro-inflammatory cytokines are involved in regulating the proliferation and apoptosis of adipocytes, promoting lipolysis, inhibiting lipid synthesis and decreasing blood lipids, etc. In recent decades, extensive studies have indicated that pro-inflammatory cytokines play important roles in the development of lipid metabolism of metabolic diseases, including obesity, atherosclerosis, steatohepatitis and hyperlipoproteinemia. However, the involved pro-inflammatory cytokines types and the underlying mechanisms remain largely unknown. The “re-discovery” of cancer as a metabolic disorder largely occurred in the last five years. Although pro-inflammatory cytokines have been intensively investigated in cancer research, there are very few studies about the roles of pro-inflammatory cytokines in the lipid metabolism of cancer. In the current review, we provide an overview of the progress that has been made in the roles of different pro-inflammatory cytokines in lipid metabolism of metabolic diseases including cancer.

Keywords:

• Lipid metabolism
• cytokine
• fatty acid
• obesity
• atherosclerosis
• steatohepatitis

Disclosure Statement

The authors declare that they have no conflict of interest.

Additional information

Funding

The authors are grateful for the support by the Project of Key issues of Tianjin Municipal Education Commission (2016YD01 to W.M.D).