Advanced search
Publication Cover
International Reviews of Immunology Volume 39, 2020 - Issue 3
Submit an article Journal homepage
979
Views
10
CrossRef citations to date
0
Altmetric
Reviews

BCG-induced trained immunity in macrophage: reprograming of glucose metabolism

BCG-induced trained immunity by enhanced glycolysis and glutamine-driven tricarboxylic acid cycle in macrophage

Yuntong LiuDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, ChinaView further author information
,
Shu LiangDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, ChinaView further author information
,
Ru DingDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, ChinaView further author information
,
Yuyang HouDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, ChinaView further author information
,
Feier DengDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, ChinaView further author information
,
Xiaohui MaDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, ChinaView further author information
,
Tiantian SongDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, ChinaView further author information
&
Dongmei YanDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun City, Jilin Province, ChinaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-8314-491XView further author information
ORCID Icon show all
Pages 83-96 | Received 05 Nov 2019, Accepted 01 Jan 2020, Published online: 14 Jan 2020
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

Memory is no longer a privilege of adaptive immunity. Innate immune cells can exhibit a long-term immune activation after infection or vaccination, which is called “trained immunity.” In addition to defense against mycobacterial infection, BCG-induced trained immunity can also exert nonspecific protection, which is regulated by metabolic rewiring and epigenetic reprograming. Enhanced glycolysis and glutamine-driven tricarboxylic acid cycle have been proven to be important metabolic pathways for trained immunity induced by BCG, which is dependent on Akt/mTOR pathway.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (Nos. 81871245) and Department of Education of Jilin Province（JJKH20190095KJ）and the Fundamental Research Funds for the Central Universities of China.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Advances and challenges in recombinant Mycobacterium bovis BCG-based HIV vaccine development: lessons learned
Source: Informa UK Limited
Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation
Source: The American Association of Immunologists
A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection
Source: Proceedings of the National Academy of Sciences
Trained Immunity: A Memory for Innate Host Defense
Source: Elsevier BV
HIF1α and metabolic reprogramming in inflammation
Source: American Society for Clinical Investigation
Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan
Source: Elsevier BV
An Evolutionary Perspective on Immunometabolism
Source: American Association for the Advancement of Science (AAAS)
BCG scar and positive tuberculin reaction associated with reduced child mortality in West Africa. A non-specific beneficial effect of BCG?
Source: Elsevier BV
BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis
Source: Elsevier BV
Pyruvate Dehydrogenase Kinase 1 Participates in Macrophage Polarization via Regulating Glucose Metabolism
Source: The American Association of Immunologists
Metabolic reprogramming of macrophages during infections and cancer.
Source: Elsevier BV
Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB
Source: Portland Press Ltd.
HIF1α-Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory Macrophages.
Source: Hindawi Limited
Nonspecific immunotherapy with BCG vaccine in bladder tumors: a preliminary report.
Source: Elsevier BV
Non-specific effects of BCG in protozoal infections: tegumentary leishmaniasis and malaria.
Source: Elsevier BV
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
Source: Apollo - University of Cambridge Repository
Nicotinamide-induced Mitophagy EVENT MEDIATED BY HIGH NAD+/NADH RATIO AND SIRT1 PROTEIN ACTIVATION
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression
Source: (:unav)
Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression.
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity.
Source: Elsevier BV
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
Source: Nature Research
BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice
Source: Elsevier BV
Oxygen sensors and angiogenesis.
Source: Elsevier BV
Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival
Source: American Society for Clinical Investigation
The lncRNA Connection Between Cellular Metabolism and Epigenetics in Trained Immunity.
Source: Frontiers Media SA
PKM2, function and expression and regulation
Source: BMC
Macrophage Polarization
Source: Annual Reviews
PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis
Source: Springer Science and Business Media LLC
Immunometabolic Crosstalk: An Ancestral Principle of Trained Immunity?
Source: Elsevier BV
PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense.
Source: The American Association of Immunologists
Citrate--new functions for an old metabolite.
Source: Walter de Gruyter GmbH
HIF Transcription Factors, Inflammation, and Immunity
Source: Elsevier Inc.
Insulin Signaling and Insulin Resistance Facilitate Trained Immunity in Macrophages Through Metabolic and Epigenetic Changes.
Source: Frontiers Media SA
Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism
Source: Proceedings of the National Academy of Sciences
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Source: The University of North Carolina at Chapel Hill University Libraries
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Source: HAL CCSD
Immunomodulation by a low-virulence, agerminative variant of Candida albicans. Further evidence for macrophage activation as one of the effector mechanisms of nonspecific anti-infectious protection.
Source: Oxford University Press (OUP)
Therapy of Venezuelan patients with severe mucocutaneous or early lesions of diffuse cutaneous leishmaniasis with a vaccine containing pasteurized Leishmania promastigotes and bacillus Calmette-Guerin: preliminary report.
Source: Instituto Oswaldo Cruz, Ministério da Saúde
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Source: Elsevier BV
SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells
Source: Springer Science and Business Media LLC
Metabolism and Epigenetics
Source: Annual Reviews
The Problem of Acquired Physiological Immunity in Plants
Source: University of Chicago Press
Moonlighting glycolytic protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH): an evolutionarily conserved plasminogen receptor on mammalian cells.
Source: Wiley
A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.
Source: Wiley
HIF-1α Is an Essential Mediator of IFN-γ–Dependent Immunity to Mycobacterium tuberculosis
Source: The American Association of Immunologists
Metabolic Reprogramming of Macrophages GLUCOSE TRANSPORTER 1 (GLUT1)-MEDIATED GLUCOSE METABOLISM DRIVES A PROINFLAMMATORY PHENOTYPE
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
The impact of cellular metabolism on chromatin dynamics and epigenetics.
Source: Springer Science and Business Media LLC
Initiation and perpetuation of NLRP3 inflammasome activation and assembly
Source: Wiley
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
Source: Nature Portfolio

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.