Abstract
Systemic lupus erythematosus (SLE), an autoimmune disease that causes multiorgan injury, has an unclear etiology and complex pathogenesis. Numerous studies have found abnormal alterations in mRNAs, proteins and/or metabolites in SLE patients. These findings have extended our understanding of the pathogenesis of SLE. Novel omics techniques, such as transcriptome, proteome and metabolome profiling, can identify and quantify large numbers of biomarkers of human diseases. However, in most cases, biological reactions are the consequences of interactions among genes, proteomes, and metabolites. Single biomolecules or signaling pathways cannot fully explain biological traits or functions. Therefore, integrative multi-omics analysis can help us systematically comprehend the intrinsic molecular mechanisms underlying biological function and pathogenesis. Integrating transcriptome, proteome, and metabolome KEGG enrichment analysis data will expand our knowledge of the pathogenesis of SLE. This review discusses the application, research progress and outlook on integrative multi-omics analysis in SLE research.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Contributorship
Wencong Song and Yong Dai initiated the idea of writing this review. Dehang Chen, Lianghong Yin, Yong Xu and Fengping Zhen created the figures and Shaoying Huang, Donge Tang, HaiyanYu, Jingquan He, Dongzhou Liu, Weier Dai shared expertise on the application of integrative analysis of Multi-Omics in SLE. All authors shared common opinions and wrote various parts of the manuscript.