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Abstract
Kidney injury molecule-1(KIM-1) is a type I membrane protein, comprising an extracellular portion and a cytoplasmic portion, which is expressed at very low levels in the normal kidney. The extracellular portion can cleave and rapidly enter tubule lumens after kidney injury, and can then be detected in the urine. It has been confirmed that the urine KIM-1 level is closely related to tissue KIM-1 level and correlated with kidney tissue damage. Not only is KIM-1 proven to be an early biomarker of acute kidney injury but it also has a potential role in predicting long-term renal outcome. This review summarizes the relationships between KIM-1 and kidney injury, especially in chronic kidney disease.
Disclosure statement
The authors declare that they have no conflict of interest. The article was published in “Chinese Journal of Clinical Medicine”, in Chinese language.
Funding
This study was funded by the National Natural Science Foundation of China (81270408, 81570666), Chinese Society of Nephrology (13030300415), Jiangsu Province’s Key Provincial Talents Program (RC201162), Six Major Talents Summit of Jiangsu Province (2010(IB10)), The Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).