Relationship between hepatitis B virus infection and chronic kidney disease in Asian populations: a meta-analysis

Abstract

Purpose: To evaluate the association of Chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD).

Methods: We searched Embase, Grateful Med, Ovid, PubMed, and the China Biological Medicine Database. A meta-analysis was performed to assess whether HBV infection plays an independent impact on the development of CKD in the general population. Relative risks of CKD (defined as reduced glomerular filtration rate or proteinuria) according to HBsAg serologic status were studied.

Results: Six eligible clinical studies (189,709 individuals in total) were included in the analysis. There was no association between HBsAg seropositive status and prevalence of CKD, the summary estimate for adjusted relative risk (RR) was 1.16 (95% confidence interval (CI), 0.78, 1.71; p = .46) according to the random-effects model, and between studies heterogeneity was noted (p values by Q test <0.001). Also, there were no significant associations between positive HBV serologic status and low eGFR (adjusted relative risk, 0.95; 95% CI, 0.72, 1.26; p = .72) or proteinuria (adjusted relative risk, 1.00; 95% CI, 0.83, 1.20; p = .99).

Conclusions: This meta-analysis shows that there was no association between exposure to HBV and the risk of developing CKD in Asian populations.

Keywords:

• Hepatitis B
• kidney disease
• proteinuria
• glomerular filtration rate

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

Tong-Dong Shi conceived the study, provided funding support, and revised the manuscript critically for important intellectual content. Qing-Chun Cai made substantial contributions to the design of the study and to acquisition, analysis, and interpretation of the data. Qing-Chun Cai, Shu-Qi Zhao, Tong-Dong Shi, and Hong Ren participated in the design of the study and in acquisition, analysis, and interpretation of data. All authors read and approved the final manuscript. This work was supported by National Nature Science Foundation of China [grant No. 81172804].