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Abstract
This article, through a review of the literature, investigates the possibility of administering certain neutral amino acids for their analgesic properties in chronic pain management. These amino acids' biochemical mechanisms of action through the endorphin system and the central serotonergic system are discussed, as is their therapeutic application. Presently, at least two neutral amino acids, L-tryptophan and D-phenylalanine, show the possibility of being clinically effective for their analgesic properties.
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Notes on contributors
Gary S. Millinger
Gary S. Millinger, D.M.D.
Dr. Millinger received his D.M.D. degree from the University of Medicine and Dentistry of New Jersey, Newark, in 1981. He then served a general practice residency at Mount Sinai Hospital, Hartford, Connecticut. In 1984 he completed a Mini-Residency in Diagnosis and Treatment of Temporomandibular Joint Dysfunction (Cranio-Mandibular Disorders) at the University of Medicine and Dentistry of New Jersey.
Dr. Millinger is in private practice in Hartford, Connecticut, and is enrolled in the Edgewise Orthodontic Program at the Institute for Graduate Dentists, New York. He belongs to the American Dental Association, the Academy of General Dentistry, and local and state societies.