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Autoimmunity Volume 36, 2003 - Issue 8
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Original Article

Interferon Targeted Genes in Host Defense

Myriam S. Kunzia The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD, USACorrespondence[email protected]
&
Paula M. Pithaa The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD, USA
Pages 457-461 | Published online: 03 Aug 2009
 
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Abstract

Type I Interferons (IFN) induce the expression of IFN-stimulated genes (ISG). The products of some of these genes have direct antiviral effects, others are involved in immunoregulation or modulate signaling pathways and gene expression, and others yet are mediators of cell growth and death. Their role in autoimmune diseases has been found to be both beneficial and detrimental.

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Related Research Data

Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response.
Source: EMBO
Reovirus receptors, cell entry, and proapoptotic signaling.
Source: Springer New York
Respiratory syncytial virus (RSV) attachment and nonstructural proteins modify the type I interferon response associated with suppressor of cytokine signaling (SOCS) proteins and IFN-stimulated gene-15 (ISG15)
Source: BioMed Central
Ubiquitin-conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection.
Source: BMC

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