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Abstract
The aim of this pilot study was to investigate any association between insulin resistance (IR) and serum levels of autoantibodies against the glutamic acid decarboxylase (GAD65Ab) among adult non-diabetic subjects.
Based on calculations of IR using the IR homeostasis model in a Swedish adult non-diabetic population (n=756) participating in the WHO MONICA-study, an insulin sensitive group (n=54, M/F:27/27) and an insulin resistant group (n=46 M/F:24/22) were identified. Serum from the subjects were analysed for the presence of GAD65Ab. There was no significant difference in GAD65Ab levels between the groups. However, there was a correlation between IR and serum GAD65Ab within the insulin sensitive group (Spearman ρ 0.4, p<0.01).
Our observation could indicate that IR could serve as an initiator or a progression factor in the autoimmune process in subjects predisposed to autoimmunity. This finding will be further investigated in a larger study including subjects with a continuum of IR.