Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP)

Ingrid M. Outschoorn Centro Nacional de Microbiologia, Unidad de Respuesta Inmune, Instituto de Salud Carlos III, Majadahonda, Madrid, 28220, Spain

Noel R. Rose Johns Hopkins Medical Institutions, Departments of Pathology and of Molecular Microbiology and Immunology, Baltimore, MD21205, USA

C. Lynne Burek Johns Hopkins Medical Institutions, Departments of Pathology and of Molecular Microbiology and Immunology, Baltimore, MD21205, USA

Tim W. Jones The University of Western Australia, Telethon Institute for Child Health Research, Centre for Child Health Research, P.O. Box 855, West Perth, WA, 6872, Australia

Ian R. Mackay Monash University Clayton, Department of Biochemistry and Molecular Biology, 3800, Victoria, Australia

Merrill J. Rowley Monash University Clayton, Department of Biochemistry and Molecular Biology, 3800, Victoria, Australia

Abstract

The genetic control of the levels of autoantibodies has rarely been examined. We examined the heritability of autoantibodies to glutamic acid decarboxylase (GAD65) in type 1 diabetes, and to thyroglobulin (Tg) in chronic lymphocytic thyroiditis and thyrotoxicosis, using regression of offspring on midparent (ROMP) methods. Levels of autoantibodies in patients and their parents were significantly correlated in thyrotoxicosis (R² = 0.569, p = 0.001), consistent with the reported Gm association, but not in chronic lymphocytic thyroiditis or type 1 diabetes. Extension of the procedure to other autoantibody disorders could be informative.

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Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP)

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Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP)

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