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Original

T cell targeted immunotherapy for autoimmune disease

&
Pages 577-596 | Received 28 Jul 2005, Accepted 17 Oct 2005, Published online: 07 Jul 2009
 

Abstract

Much emphasis has been placed on the so-called “biologics” in the treatment of immune disorders within the last few years. Here we discuss the expanding horizon of potential strategies for immunotherapies targeting T lymphocytes as key effectors and regulators of autoimmunity. We review emerging reagents in a variety of animal models and human disorders that may offer new therapeutic options in current or modified iterations.

Abbreviations
ACR=

American College of Rheumatology

ADCC=

Antibody dependent cellular cytotoxicity

APL=

Altered peptide ligand

CIA=

Collagen-induced arthritis

CRS=

Cytokine release syndrome

DTH=

Delayed type hypersensitivity

EAE=

Experimental autoimmune encephalitis

EDSS=

Extended disability status scale

GVHD=

Graft versus host disease

HLA=

Human leukocyte antigen

IDDM=

Insulin dependent diabetes mellitus

IFN-γ=

Interferon gamma

LFA=

Lymphocyte function-associated antigen

mAb=

Monoclonal antibody

MBP=

Myelin basic protein

MHC=

Major histocompatibility complex

MS=

Multiple sclerosis

MTX=

Methotrexate

PASI=

Psoriasis area and severity index

PsAr=

Psoriatic Arthritis

PV=

Pemphigus vulgaris

RA=

Rheumatoid arthritis

RCT=

Randomized clinical trial

SLE=

Systemic lupus erythematosis

TCR=

T cell receptor

TCV=

T cell vaccine

TID=

Type I diabetes

TNF=

Tumor necrosis factor

UC=

Ulcerative colitis

Abbreviations
ACR=

American College of Rheumatology

ADCC=

Antibody dependent cellular cytotoxicity

APL=

Altered peptide ligand

CIA=

Collagen-induced arthritis

CRS=

Cytokine release syndrome

DTH=

Delayed type hypersensitivity

EAE=

Experimental autoimmune encephalitis

EDSS=

Extended disability status scale

GVHD=

Graft versus host disease

HLA=

Human leukocyte antigen

IDDM=

Insulin dependent diabetes mellitus

IFN-γ=

Interferon gamma

LFA=

Lymphocyte function-associated antigen

mAb=

Monoclonal antibody

MBP=

Myelin basic protein

MHC=

Major histocompatibility complex

MS=

Multiple sclerosis

MTX=

Methotrexate

PASI=

Psoriasis area and severity index

PsAr=

Psoriatic Arthritis

PV=

Pemphigus vulgaris

RA=

Rheumatoid arthritis

RCT=

Randomized clinical trial

SLE=

Systemic lupus erythematosis

TCR=

T cell receptor

TCV=

T cell vaccine

TID=

Type I diabetes

TNF=

Tumor necrosis factor

UC=

Ulcerative colitis

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