Abstract
Much emphasis has been placed on the so-called “biologics” in the treatment of immune disorders within the last few years. Here we discuss the expanding horizon of potential strategies for immunotherapies targeting T lymphocytes as key effectors and regulators of autoimmunity. We review emerging reagents in a variety of animal models and human disorders that may offer new therapeutic options in current or modified iterations.
Abbreviations | ||
ACR | = | American College of Rheumatology |
ADCC | = | Antibody dependent cellular cytotoxicity |
APL | = | Altered peptide ligand |
CIA | = | Collagen-induced arthritis |
CRS | = | Cytokine release syndrome |
DTH | = | Delayed type hypersensitivity |
EAE | = | Experimental autoimmune encephalitis |
EDSS | = | Extended disability status scale |
GVHD | = | Graft versus host disease |
HLA | = | Human leukocyte antigen |
IDDM | = | Insulin dependent diabetes mellitus |
IFN-γ | = | Interferon gamma |
LFA | = | Lymphocyte function-associated antigen |
mAb | = | Monoclonal antibody |
MBP | = | Myelin basic protein |
MHC | = | Major histocompatibility complex |
MS | = | Multiple sclerosis |
MTX | = | Methotrexate |
PASI | = | Psoriasis area and severity index |
PsAr | = | Psoriatic Arthritis |
PV | = | Pemphigus vulgaris |
RA | = | Rheumatoid arthritis |
RCT | = | Randomized clinical trial |
SLE | = | Systemic lupus erythematosis |
TCR | = | T cell receptor |
TCV | = | T cell vaccine |
TID | = | Type I diabetes |
TNF | = | Tumor necrosis factor |
UC | = | Ulcerative colitis |
Abbreviations | ||
ACR | = | American College of Rheumatology |
ADCC | = | Antibody dependent cellular cytotoxicity |
APL | = | Altered peptide ligand |
CIA | = | Collagen-induced arthritis |
CRS | = | Cytokine release syndrome |
DTH | = | Delayed type hypersensitivity |
EAE | = | Experimental autoimmune encephalitis |
EDSS | = | Extended disability status scale |
GVHD | = | Graft versus host disease |
HLA | = | Human leukocyte antigen |
IDDM | = | Insulin dependent diabetes mellitus |
IFN-γ | = | Interferon gamma |
LFA | = | Lymphocyte function-associated antigen |
mAb | = | Monoclonal antibody |
MBP | = | Myelin basic protein |
MHC | = | Major histocompatibility complex |
MS | = | Multiple sclerosis |
MTX | = | Methotrexate |
PASI | = | Psoriasis area and severity index |
PsAr | = | Psoriatic Arthritis |
PV | = | Pemphigus vulgaris |
RA | = | Rheumatoid arthritis |
RCT | = | Randomized clinical trial |
SLE | = | Systemic lupus erythematosis |
TCR | = | T cell receptor |
TCV | = | T cell vaccine |
TID | = | Type I diabetes |
TNF | = | Tumor necrosis factor |
UC | = | Ulcerative colitis |