Clearance of dying cells and autoimmunity

Review

Sylwia Michlewska The Queen's Medical Research Institute, MRC Centre for Inflammation Research, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK

Aisleen McColl The Queen's Medical Research Institute, MRC Centre for Inflammation Research, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK

Adriano G Rossi The Queen's Medical Research Institute, MRC Centre for Inflammation Research, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK

Ian L Megson UHI Millennium Institute, The Green House, Beechwood Business Park North, Inverness, IV2 3BL, Scotland, UK

Ian Dransfield The Queen's Medical Research Institute, MRC Centre for Inflammation Research, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK

Abstract

Phagocytic clearance of apoptotic cells is an important physiologic homeostatic mechanism that is associated with non-inflammatory or anti-inflammatory sequalae. Disruption of the process of apoptotic cell clearance may contribute to development of a number of inflammatory and autoimmune diseases. In this review, we summarize the molecular pathways that have been suggested to account for phagocytic clearance of apoptotic cells. We discuss potential mechanisms for regulation of phagocytosis and the implications for development of autoimmunity.

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Acknowledgements

The Funding support of the Wellcome Trust and the Medical Research Council is gratefully acknowledged.

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Clearance of dying cells and autoimmunity

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Clearance of dying cells and autoimmunity

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