TIM family proteins and autoimmunity

Abstract

Despite their relative novelty, a growing body of literature now demonstrates that T cell immunoglobulin and mucin domain (TIM) family proteins are important regulators of immunity. Not surprisingly, these proteins also play prominent roles in the control of auto-reactive immune responses. Thus, modulation of TIM protein function may prove to be a useful strategy to control autoimmune diseases.

• T cell immunoglobulin and mucin (TIM)
• autoimmune diseases
• rheumatoid arthritis (RA)
• antigen presenting cells (APC)
• experimental autoimmune encephalomyelitis (EAE)