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Role of CCR5 Δ32 bp deletion in RA and SLE

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Pages 260-262 | Received 09 Sep 2008, Accepted 07 Jan 2009, Published online: 13 Aug 2009
 

Abstract

CCR5 and its ligands play important roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A deletion of 32 bp in its gene leads to the production of a non-functional receptor. Although a protective effect of CCR5 Δ32 for the development of RA has been suggested, future study is required to establish the exact role of this deletion for susceptibility to SLE and lupus nephritis. Also, with regard to the association of CCR5 Δ32 with disease severity in RA and SLE, more data are needed to draw firm conclusions. This might become even more relevant as a CCR5 blocking agent is now available.

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