Activation-induced cell death and total Akt content of granulocytes show a biphasic course after low-dose radiation

Brief definite report

U. S. Gaipl Department of Radiation Oncology, University of Erlangen-Nuremberg, D-91054, Erlangen, Germany

S. Meister Interdisciplinary Centre for Clinical Research Group 2, Nikolaus-Fiebiger-Center of Molecular Medicine, Friedrich-Alexander-University Erlangen-Nuremberg, D-91054, Erlangen, Germany

B. Lödermann Department of Radiation Oncology, University of Erlangen-Nuremberg, D-91054, Erlangen, Germany

F. Rödel Department of Radiotherapy and Oncology, University Hospital of Frankfurt, Frankfurt, Germany

R. Fietkau Department of Radiation Oncology, University of Erlangen-Nuremberg, D-91054, Erlangen, Germany

M. Herrmann Department for Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, D-91054, Erlangen, Germany

P. M. Kern Department of Internal Medicine and Rheumatology, Capio Franz von Pruemmer Hospital, D-97769, Bad Brueckenau, GermanyCorrespondence[email protected]

B. Frey Department of Radiation Oncology, University of Erlangen-Nuremberg, D-91054, Erlangen, Germany

show all

Abstract

Low-dose radiation (single doses from 0.3 to 1.0 Gy) in clinical practice is mostly used to treat patients with several inflammatory diseases and painful degenerative disorders. Low-dose radiation is known to exert anti-inflammatory effects. However, the molecular and cellular mechanism are not fully analysed and most of the observed effects are based on empirical studies. We investigated the effects of low-dose radiation on the activation-induced cell death of polymorph nuclear granulocytes (PMN). A biphasic appearance of cell death in irradiated PMN was observed, displaying a relative maximum at 0.3 Gy and minimum at 0.5 Gy, respectively. This biphasic course of cell death was coincident with the protein level of total cellular Akt. We conclude that low-dose radiation exerts immunomodulatory effects on PMN contributing to the observed anti-inflammatory effects in clinical applications.

Keywords

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Activation-induced cell death and total Akt content of granulocytes show a biphasic course after low-dose radiation

Brief definite report

Information for

Open access

Opportunities

Help and information

Activation-induced cell death and total Akt content of granulocytes show a biphasic course after low-dose radiation

Brief definite report

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature