Recent advances of exosomes in immune modulation and autoimmune diseases

Lina TanDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, P.R. China, ;Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, P.R. China, and

Haijing WuDepartment of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, P.R. China, and

Ying LiuDepartment of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, P.R. China, and

Ming ZhaoDepartment of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, P.R. China, and

Duo LiDepartment of Pathology, Second Xiangya Hospital, Central South University, Changsha, P.R. China

Qianjin LuDepartment of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, P.R. China, and Correspondence[email protected]

Abstract

Exosomes are small membrane-bound vesicles (30-100 nm) that are secreted by different types of cells and they have been well documented to resemble saucers or flattened spheres under the electron microscope. Recently, evidence indicates that exosomes play important roles in the immune modulation and are associated with the immune pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA), Sjogren’s syndrome (SS) and systemic lupus erythematosus (SLE). In this review, we will summarize current research advances of exosomes in immunoregulation, pathogenesis, diagnosis and therapeutics of autoimmune diseases.

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Declaration of interest

The authors declare that they have no competing interests. This study was supported by the National Natural Science Foundation of China (No. 81220108017).

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Recent advances of exosomes in immune modulation and autoimmune diseases

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