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Research Article

Anti-inflammatory activity of Motherwort (Leonurus sibiricus L.)

, , , , , , , , & show all
Pages 209-213 | Received 29 Mar 2008, Accepted 29 Oct 2008, Published online: 01 Jun 2008
 

Abstract

Motherwort (MW), a Korean folk medicine, has been applied to treat inflammatory disease. However, its effect on inflammatory cytokine release from mast cells is not well known. We investigated the anti- inflammatory effect of MW on the secretion of inflammatory cytokine such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 and IL-8 in human mast cell line (HMC-1). MW was treated in vitro before activation of HMC-1 cells with phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187. MW had no cytotoxic effects on HMC-1 cell viability. MW (1 mg/ml) inhibited PMA plus A23187-stimulated gene expression and production of TNF-α, IL-6, and IL-8. Stimulation with PMA plus A23187 induced NF-κB activation in HMC-1 cells, which was inhibited by MW (1 mg/ml). MW inhibited secretion of TNF-α, IL-6, and IL-8 possibly by inhibiting NF-κB activation. These results indicate that MW may be helpful in regulating inflammatory diseases.

Acknowledgments

This work was supported by Korean Research Foundation Grant funded by the South Korean government (MOEHRD) (The Regional Research Universities Program/Center for Healthcare Technology Development), by the South Korean government (MOST) (No. M10646020001-06N4602-00110), and by the MRC program of MOST/KOSEF (grant #: R13-2005-013-01000-0).

Declaration of interest: The authors report no conflicts of interest.

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