Is resveratrol really effective in kidney disease?: A different perspective than ever before

Abstract

Background

Chronic kidney disease (CKD) is a global health problem and it is stated that the use of resveratrol supplement contributes to the protection of kidney health. In this study, it was aimed to evaluate the effect of resveratrol supplementation on kidney function, inflammation and histopathological findings in rats with experimental adenine-induced kidney damage.

Methods

Three different groups of 10 randomly selected rats were formed. The first group was the negative control group, the second group was the uremic control group (KDG), and the third group was the group in which uremia was created and resveratrol was applied (RG). Kidney damage was induced by administration of 200 mg/kg adenine. Resveratrol supplementation was administered at 20 mg/kg after kidney damage. Serum urea, creatinine, indoxyl sulfate (IS), p-cresol, glomerular filtration rate, C-reactive protein (CRP); interleukin (IL)-6 and tumor necrosis factor (TNF)-α gene expression levels and histopathological findings were evaluated.

Results

It was determined that resveratrol supplement applied after the formation of connective tissue in renal failure didn’t have an improvement effect on the urine amount, kidney function and inflammatory parameters and histopathological changes (p > 0.05). Just, the increase in the CRP value of KDG (p < 0.05) was not observed in RG.

Conclusion

The findings suggest that resveratrol administered after kidney damage with adenine has no effect on kidney disease.

Keywords:

• Adenine
• chronic kidney disease
• C-reactive protein
• inflammation
• resveratrol

Author contributions

Sümeyye Kemaneci: Methodology, Investigation, Resources, Data curation, Formal Analysis, Writing–Original Draft, Review&Editing, Funding acquisition.

Alev Keser: Methodology, Funding Acquisition, Review&Editing and Supervision.

Özlem Özmen: Formal Analysis, Review&Editing and Supervision. All authors read and approved the final manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by Ankara University Scientific Research Projects under Grant number 21L0241003.