Development of a Human to Murine Orthotopic Xenotransplanted Lung Cancer Model

Roger A. Vertrees Phd Ccp, Donald J. Deyo, Mike Quast, Kelly M. Lightfoot, Paul J. Boor, Joseph B. Zwischenberger Department of Surgery, Division of Cardiothoracic Surgery, University of Texas Medical Branch, Galveston, Texas, USA; Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, USA; Marine Biological Institute, Marie Hall Magnet Lab, University of Texas Medical Branch, Galveston, Texas, USA; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA; Department of Surgery, Division of Cardiovascular Surgery, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

The goal was to develop a clinically relevant animal model that could be used to assess the efficacy of therapeutic interventions in lung cancer. Two cell lines, noncancerous control (BEAS2-B, immortalized human bronchial-epithelial cell line) and cancerous (BZR-T33, H-ras transformed BEAS2-B) were implanted into nude (athymic) mice. Two groups (n

Keywords

Lung Cancer Metastatic Disease Xenotransplantation

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Development of a Human to Murine Orthotopic Xenotransplanted Lung Cancer Model

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Development of a Human to Murine Orthotopic Xenotransplanted Lung Cancer Model

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