Effect of Lazaroid U-74389G on Pulmonary Ischemia - Reperfusion Injury in Dogs

Izumi Takeyoshi Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan

Kotaro Iwanami Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan

Norikazu Kamoshita Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan

Toru Takahashi Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan

Junya Kobayashi Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan

Naoki Tomizawa Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan

Yoshiyuki Kawashima Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan

Koshi Matsumoto Department of Pathology, Nippon Medical School, Kawasaki, Kanagawa, Japan

Yasuo Morishita Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan

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Abstract

Lipid peroxidation induced by oxygen free radicals is a contributing factor in ischemia-reperfusion injury. Lazaroid U-74389G (LAZ-G) is a group of new synthetic 21-aminosteroids and inhibits irondependent lipid peroxidation. We investigated the effects of LAZ-G on pulmonary ischemia-reperfusion injury in dogs. Twenty dogs were divided into three groups. In the LAZ-G group (

Keywords

Interleukin Beta Lazaroid U-74389G Lipid Peroxidation Pulmonary Ischemia-REPERFUSION Injury

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Effect of Lazaroid U-74389G on Pulmonary Ischemia - Reperfusion Injury in Dogs

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Effect of Lazaroid U-74389G on Pulmonary Ischemia - Reperfusion Injury in Dogs

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