Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain

Victoria A. Hampshire Laboratory of Immunogenetics and the Office of the Scienti.c Director, National Institute of Allergy and Infectious Diseases; the Veterinary Resources Program, Office of Research Services, and the Office of Intramural Research, Office of the Director, and Biostatistics Section, Warren Grant Magnuson Clinical Center; National Institutes of Health, Bethesda, Maryland, USA

Marvin L. Thomas Laboratory of Immunogenetics and the Office of the Scienti.c Director, National Institute of Allergy and Infectious Diseases; the Veterinary Resources Program, Office of Research Services, and the Office of Intramural Research, Office of the Director, and Biostatistics Section, Warren Grant Magnuson Clinical Center; National Institutes of Health, Bethesda, Maryland, USA

John D. Bacher Laboratory of Immunogenetics and the Office of the Scienti.c Director, National Institute of Allergy and Infectious Diseases; the Veterinary Resources Program, Office of Research Services, and the Office of Intramural Research, Office of the Director, and Biostatistics Section, Warren Grant Magnuson Clinical Center; National Institutes of Health, Bethesda, Maryland, USA

David W. Alling Laboratory of Immunogenetics and the Office of the Scienti.c Director, National Institute of Allergy and Infectious Diseases; the Veterinary Resources Program, Office of Research Services, and the Office of Intramural Research, Office of the Director, and Biostatistics Section, Warren Grant Magnuson Clinical Center; National Institutes of Health, Bethesda, Maryland, USA

Thomas J. Kindt Laboratory of Immunogenetics and the Office of the Scienti.c Director, National Institute of Allergy and Infectious Diseases; the Veterinary Resources Program, Office of Research Services, and the Office of Intramural Research, Office of the Director, and Biostatistics Section, Warren Grant Magnuson Clinical Center; National Institutes of Health, Bethesda, Maryland, USA

Richard G. Wyatt Laboratory of Immunogenetics and the Office of the Scienti.c Director, National Institute of Allergy and Infectious Diseases; the Veterinary Resources Program, Office of Research Services, and the Office of Intramural Research, Office of the Director, and Biostatistics Section, Warren Grant Magnuson Clinical Center; National Institutes of Health, Bethesda, Maryland, USA

R. Mark Simpson Laboratory of Immunogenetics and the Office of the Scienti.c Director, National Institute of Allergy and Infectious Diseases; the Veterinary Resources Program, Office of Research Services, and the Office of Intramural Research, Office of the Director, and Biostatistics Section, Warren Grant Magnuson Clinical Center; National Institutes of Health, Bethesda, Maryland, USA

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Abstract

Diminished tissue injury and shortened clinical recovery are benefits of using an endoscopic approach for patients needing operative procedure. In the course of developing an experimental model requiring procurement of topographically precise lung biopsy specimens, we sought to apply thoracoscopy as a research alternative to thoracotomy. In addition, we investigated the influence of thoracoscopy on postprocedure recovery practices using rabbits divided into four treatment groups. Rabbit groups 1 and 2 underwent thoracoscopy and lung biopsy while maintained by one-lung anesthesia. Additionally, group 2 had ketoprofen and bupivacaine HCl analgesics injected for treatment during postprocedure recovery. These two groups were compared to control rabbits in groups 3 and 4, which underwent inhalant anesthesia without thoracoscopy. Control group 3 also received the injection analgesic combination. During recovery, rabbit behavior was systematically assessed for evidence of pain. No behavior considered indicative of pain needing intervention was observed regardless of treatment group. Limited changes in plasma corticosterone, catecholamines, and prostaglandin E₂ levels measured during recovery were difficult to associate with any treatment. Unexpectedly, significantly different mean corticosterone and catecholamines levels were detected in rabbits given the injection analgesic combination in the absence of thoracoscopic procedure, as compared to other treatment groups. The results highlight the importance of awareness that analgesic drug administration has the potential to alter homeostasis and affect interpretation of some study findings by its own guise. Correlation of the mean pain study results with plasma biochemical data supports preferential use of thoracoscopy as a refinement for limiting postprocedural pain in research models.

Keywords

Disease Model Animals Endoscopy Nonsteroidal Anti-INFLAMMATORY Agents Therapeutic Toxic Effects One-LUNG Anesthesia Pain Measurement Veterinary Research Procedures

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Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain

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Thoracoscopy as a Nonpharmacotherapeutic Research Modification for Limiting Postoperative Chest Pain

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