Fas Deficiency Exacerbates Cerulein-Induced Pancreatitis

D. Rohan Jeyarajah Departments of Surgery, Internal Medicine and Pathology, University of Texas Southwestern Medical School, Dallas, Texas, USA

M. Kielar Departments of Surgery, Internal Medicine and Pathology, University of Texas Southwestern Medical School, Dallas, Texas, USA

S. T. Gokaslan Departments of Surgery, Internal Medicine and Pathology, University of Texas Southwestern Medical School, Dallas, Texas, USA

G. Lindberg Departments of Surgery, Internal Medicine and Pathology, University of Texas Southwestern Medical School, Dallas, Texas, USA

C. Y. Lu Departments of Surgery, Internal Medicine and Pathology, University of Texas Southwestern Medical School, Dallas, Texas, USA

Abstract

Acute pancreatitis results in many deaths each year. Our understanding of the pathophysiology is limited. To better understand the impact of apoptosis versus necrosis, we compared cerulein-induced pancreatitis in Fas-deficient (MRL lpr/lpr) versus Fas-sufficient (MRL +/+) mice. Average amylase values in Fas-deficient mice were substantially greatr than in the Fas-sufficient mouse. Histology graded on edema, inflammation, vacuolization, and necrosis showed greater injury in the Fas-deficient mouse. This finding suggests that the Fas pathway is important in controlling cerulein-induced pancreatitis.

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Fas Deficiency Exacerbates Cerulein-Induced Pancreatitis

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Fas Deficiency Exacerbates Cerulein-Induced Pancreatitis

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