Intravenous Infusion Anesthesia with Propofil–Midazolam–Fentanyl for Experimental Surgery in Swine

Gernot M. Kaiser Department of General Surgery and Transplantation, University Hospital, Essen, Germany

Nils R. Frühauf Department of General Surgery and Transplantation, University Hospital, Essen, Germany

Hongwei Zhang Department of General Surgery and Transplantation, University Hospital, Essen, Germany

Stephanie Westermann Department of General Surgery and Transplantation, University Hospital, Essen, Germany

Ines Bolle Animal Laboratory, University Hospital, Essen, Germany

Karl J. Oldhafer Department of General Surgery and Transplantation, University Hospital, Essen, Germany

Christoph E. Broelsch Department of General Surgery and Transplantation, University Hospital, Essen, Germany

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Abstract

There is a need for prolonged anesthesia procedures in experimental surgery. Animals in this study receivd fentanyl, Midazolam, and Propofol administered by continuous intravenous infusion for anesthesia along with controlled ventilation. Time of anesthesia was 413 ± 95 min. Animals could be extubated 20 ± 12 min after operation. Animals recovered completely from anesthesia by day 1 after surgery with almost normal physical activity. This study clearly shows that intravenous infusion anesteshia is safe and easy to handle in prolonged anesthesia for experimental surgery in swine. This anesthetic protocol can also be used for intraoperative transportation.

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Intravenous Infusion Anesthesia with Propofil–Midazolam–Fentanyl for Experimental Surgery in Swine

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Intravenous Infusion Anesthesia with Propofil–Midazolam–Fentanyl for Experimental Surgery in Swine

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