Effectiveness of Hypericum perforatum Extract in the Treatment of Corrosive Esophageal Burns

Abstract

Purpose

The purpose of our study is to determine the effectiveness of “Hypericum perforatum” extract in corrosive esophageal burns and to shed light on the search for new treatments.

Materials and methods

A total of 32 Sprague Dawley rats were separated into 4 groups. A standard esophageal burn model was created. Group 1 was identified as the sham group. Group 2 was burned and no treatment was performed afterward. Group 3 was burned and then 2 cc/day H. perforatum extract was given for 21 days. Group 4 was not applied any process and 2 cc/day H. perforatum extract was given for 21 days. The rats were sacrificed and biopsy specimens were taken for histopathological examination for the presence of inflammation, fibrosis, and necrosis.

Results

There was a significant difference between groups in terms of inflammation, fibrosis, and necrosis. Furthermore, in the bilateral comparisons between the groups, there was a meaningful difference in terms of inflammation and fibrosis between Group 2 and Group 3. However, there was no meaningful difference between the same groups in terms of necrosis.

Conclusion

H. perforatum extract may be effective on inflammation, fibrosis, and necrosis in corrosive esophageal burns.

Keywords:

• Corrosive esophagus
• Hypericum perforatum
• inflammation
• fibrosis
• necrosis
• esophageal strictures

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethical approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed (ethical approval number was 2017-40).