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Abstract
High pressure (HP) technology appears to be of paramount interest for valuable applications in pharmacy and medicine, owing to academic studies and industrial developments of this technology for food processing. The main potential application of HP between 100 MPa and 1200 MPa (1 kbar to 12kbar) is the inactivation of biological agents (bacteria, moulds, yeasts, virus and even prions) which allows the sterilization (i.e, “pascalization”) of thermo-, chemo-, or radio-sensitive materials and chemicals. The immunogenicity of some pressure-killed bacteria or virus suggests also the potentiality of making new vaccines. Another interest of the HP technology is the possibility of storage at subzero temperatures without freezing of cells and animal tissues to be used for cells and organs for transplant. HP engineering may be used for enzyme-catalyzed synthesis of fine chemicals, production of modified proteins of medical or pharmaceutical interest, and organic synthesis of pharmaceuticals.