Publication Cover
High Pressure Research
An International Journal
Volume 19, 2000 - Issue 1-6
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Original Articles

Pressure-assisted cold unfolding of proteins and its effects on the conformational stability compared to pressure and heat unfolding

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Pages 263-268 | Received 09 Sep 1999, Published online: 19 Aug 2006
 

Abstract

The pressure-assisted cold unfolding of metmyoglobin was investigated and the cold unfolded state was compared to the heat and pressure unfolded states. Conformationally and mechanistically the pressure and cold unfolding processes are found to be very alike, while the heat unfolding shows some pronounced differences. We also propose a hypothesis on protein aggregation.

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