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High Pressure Research
An International Journal
Volume 24, 2004 - Issue 1
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Original Articles

High pressure relief of steric inhibition in ionogenic organic reactions

Pages 163-168 | Received 16 May 2003, Accepted 22 Sep 2003, Published online: 08 Jun 2010
 

Abstract

The pressure effect is examined in an ionogenic reaction, the phosphine-catalyzed cyanoalkylation of acrylic nitriles by primary alcohols. The increase of rate constants with pressure is enhanced with increasing chain length of the alcohol and depends on steric constraints imposed by the substituting methyl group in the acrylic compound. The pressure effect is in line with a considerable electrostriction depending on steric hindrance to ionization. Pressure is confirmed as a favorable determining factor in sterically hindered reactions.

This paper is dedicated to the memory of J. M. Besson.

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