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Bio and food sciences

High-resolution structures and properties of biomolecules under high pressures probed by X-ray crystallography

, , , , , & show all
Pages 100-103 | Received 07 Nov 2009, Published online: 17 Mar 2010
 

Abstract

Modern macromolecular crystallography has the potential, together with NMR, to provide an accurate description of structural changes produced by pressure in a macromolecular system. In particular, promoting and trapping higher-energy conformations of biological significance is of particular interest to explore functional mechanisms. An overview of this technique is given, including instrumentation and selected applications. This method is now fully-fledged and would deserve more interest from the structural biology community.

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