Recent advances in the organic synthesis at high pressure. Effect of pressure on the macrocyclization reaction

Abstract

α,ω-Tertiary diamines react under high pressure with α,ω-di-iodo compounds to give cyclic or bicyclic bis-quaternary salts in almost quantitative yields. The role of high-pressure-induced changes in conformation of linear intermediates and the viscosity factor are discussed.

Key Words:

• Menshutkin reaction
• quaternary ammonium salts
• N, N'-dimethyl diazacoronands
• cryptands
• conformation
• viscosity