Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 12, 2000 - Issue 8
28
Views
2
CrossRef citations to date
0
Altmetric
Research Article

COMBINED RESPIRATORY EFFECTS OF COLD AIR WITH SO2 OR NO2 IN REPEATED 10-MINUTE EXPOSURES OF HYPERVENTILATING GUINEA PIGS

Pages 671-691 | Published online: 01 Oct 2008
 

Abstract

Previous studies in asthmatic subjects and guinea pigs have demonstrated attenuation of bronchoconstriction in repeated exposures to clean cold dry air. In the present animal study, we have simulated short-lasting human exposures to subfreezing urban air containing sulfur dioxide (SO2) and nitrogen dioxide (NO2). The anesthetized, paralyzed, and mechanically ventilated guinea pigs had 4 consecutive 10-min exposures either to clean cold dry air or to cold air with graded concentrations of SO2 (0-5 ppm) or NO2 (0-4 ppm). Peak expiratory flow (PEF) and tidal volume (VT

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.