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Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 3
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Research Article

MICRONUCLEI INDUCED BY SULFUR DIOXIDE INHALATION IN MOUSE BONE-MARROW CELLS IN VIVO

Ziqiang Meng Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan, People's Republic of China
,
Bo Zhang Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan, People's Republic of China
,
Aidong Ruan Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan, People's Republic of China
,
Nan Sang Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan, People's Republic of China
&
Jianbiao Zhang Institute of Environmental Medicine and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan, People's Republic of China
Pages 303-309 | Published online: 01 Oct 2008
 
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Abstract

Induction effects of sulfur dioxide (SO 2) inhalation on micronuclei (MN) formation in the polychromatic erythrocytes (PCE) of mouse bone marrow were studied in vivo. It was shown that SO 2 inhalation caused an increase of MN frequencies in the PCE cells in a dose-dependent manner. These results from male and female mice were very similar; no sex difference was observed. These results imply that SO 2 is a clastogenic and genotoxic agent.

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