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Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 31, 2018 - Issue 3
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Case Studies

Disseminated infection to immune activation

, DO, ORCID Icon & (MD)
Pages 345-346 | Received 11 Mar 2018, Accepted 12 Apr 2018, Published online: 16 May 2018
 

ABSTRACT

A 61-year-old woman with rheumatoid arthritis on chronic immunosuppression presented with fever. Laboratory studies demonstrated multiorgan failure with pancytopenia, elevation in liver function studies, and an elevated ferritin level, with a diagnosis of hemophagocytic lymphohistiocytosis confirmed on bone marrow biopsy. After initial treatment with chemotherapy, fungal blood cultures grew Histoplasma, prompting initiation of antifungal therapy, which resulted in successful treatment of Histoplasma-associated hemophagocytic lymphohistiocytosis.

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