Partial Fanconi syndrome induced by ifosfamide

Abstract

Ifosfamide-induced proximal tubular nephropathy can present as a spectrum of disease, from isolated hyperaminoaciduria to a partial or complete Fanconi syndrome. We report a case of ifosfamide-induced partial Fanconi syndrome in a man with metastatic progressive Ewing sarcoma and put forth a hypothesis on the mechanism.

Keywords:

• Acrolein
• chloroacetaldehyde
• Ewing sarcoma
• Fanconi syndrome
• hyperaminoaciduria
• ifosfamide
• Na-K-ATPase
• nephrotoxicity
• proximal tubulopathy