Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis syndrome and collapsing focal segmental glomerulosclerosis

Abstract

Collapsing glomerulopathy is a distinct and aggressive clinicopathologic variant of focal segmental glomerulosclerosis (FSGS). Here we present a 46-year-old man with acute renal failure from biopsy-proven collapsing FSGS and nephrotic syndrome in the setting of a diagnosis of hemophagocytic lymphohistiocytosis secondary to acute Epstein-Barr virus infection. This rare association has not been well described previously.

Keywords:

• Collapsing focal segmental glomerulosclerosis
• Epstein-Barr virus
• hemophagocytic lymphohistiocytosis