Publication Cover
Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 35, 2022 - Issue 3
98
Views
1
CrossRef citations to date
0
Altmetric
Case Studies

Immediate reconstruction of segmental mandibular defects via tissue engineering

, DDS, MD, , DDS, MD & , DDS, MD
Pages 391-393 | Received 18 Feb 2021, Accepted 24 Jan 2022, Published online: 03 Mar 2022
 

Abstract

Ameloblastomas are benign, locally invasive odontogenic tumors that comprise approximately 1% of tumors within the jaws, with 66% located in the posterior mandible. If left untreated, these lesions can reach enormous size, resulting in considerable deformity and associated morbidity. Traditionally, defects >6 cm warranted a free-flap fibula transfer or iliac crest autogenous graft. Surgical treatment for the two presented cases included a large (>6 cm) mandibular segmental resection with immediate reconstruction via a tissue-engineering protocol that included bone morphogenetic protein (rhBMP-2), bone marrow aspirate concentrate, and cortical bone chips. Both patients had an uneventful postoperative course and healed satisfactorily. Established bone reconstruction determinants include bone volume, facial counter, esthetics, and restoration of functionality. Advances in tissue engineering provide a legitimate alternative while decreasing the risks, length of hospital stay, and postoperative morbidity.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.