Facial diplegia with paresthesia associated with anti-GD1a antibodies

Jason Strawbridgea David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CaliforniaCorrespondence[email protected]

, BA,

Katherine A. Fub Department of Neurology, University of California, Los Angeles, Los Angeles, California

, MD,

Joy Chanc Sacramento VA Medical Center, Sacramento, California

, MD,

William Flavinb Department of Neurology, University of California, Los Angeles, Los Angeles, California

, MD, PhD,

Joss Cohenb Department of Neurology, University of California, Los Angeles, Los Angeles, California

, MD,

Inna Keselmanb Department of Neurology, University of California, Los Angeles, Los Angeles, California

, MD, PhD &

Perry Shiehb Department of Neurology, University of California, Los Angeles, Los Angeles, California

, MD, PhD show all

Abstract

A 26-year-old previously healthy man presented with progressive facial diplegia and sensory deficits to pinprick in a stocking-glove distribution. Lumbar puncture revealed cytoalbuminologic dissociation, and a nerve conduction study of the right facial nerve demonstrated a proximal demyelinating process. He was started on intravenous immunoglobulin given concern for a Guillain-Barré syndrome variant, and his symptoms improved over several days. This case illustrates the clinical features of facial diplegia with paresthesias, a rare variant of Guillain-Barré syndrome. Unlike most reported cases of facial diplegia with paresthesias that have demonstrated positive anti-ganglioside M2 antibodies, this case is unique given the positivity of anti-ganglioside D1a IgG/IgM antibodies.

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Facial diplegia with paresthesia associated with anti-GD1a antibodies

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Facial diplegia with paresthesia associated with anti-GD1a antibodies

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