Adverse cutaneous reaction to hydroxychloroquine in a patient with anti-SAE-1-positive dermatomyositis and a history of diffuse large B-cell lymphoma

Abstract

This case report details the cutaneous findings of a patient with a history of diffuse B-cell lymphoma and SAE-1–positive dermatomyositis who developed an adverse cutaneous reaction after initiation of treatment with hydroxychloroquine. This adds to the sparse literature available detailing the correlation between anti–SAE-1 autoantibodies in dermatomyositis and the unique adverse cutaneous reactions in patients taking hydroxychloroquine. Additionally, our patient developed dermatomyositis years after a diagnosis of lymphoma. This report highlights the utility of the myositis-specific antibody panel to guide diagnosis and management, as well as the potential for developing dermatomyositis years after a lymphoma diagnosis.

Keywords:

• Adverse cutaneous reactions
• B-cell lymphoma
• dermatomyositis
• hydroxychloroquine

Conflict of Interest

The authors report no funding or conflicts of interest.

Disclosure statement

Permission was obtained from the patient for publication of this case and use of clinical photos, including those of her face.