![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
We investigated to determine whether a variety of acyl-homoserine lactones (AHLs) influences epithelial cell proliferation and mucosal permeability. 3-Oxo-C12-homoserine lactone (HSL) and 3-oxo-C14-HSL significantly suppressed IEC-6 cell proliferation. A significant increase in mucosal permeability was observed in isolated rat colon tissue exposed to C12-HSL, 3-oxo-C12-HSL, and 3-oxo-C14-HSL. These data indicate that AHLs suppress epithelial proliferation and disrupt barrier function in intestinal mucosa.
Acknowledgment
We thank the Regional Innovation Strategy Support Program of the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of the Japanese Government for financial support for S.I.
Notes
Abbreviations: AHL, acyl-homoserine lactone; HSL, homoserine lactone; DMEM, Dulbecco’s modified eagle medium; DMSO, dimethylsulfoxide; HBSS, Hank’s balanced salt solution; LY, Lucifer yellow.