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Abstract
The ginsenosides in Panax ginseng have vast structural and pharmacological efficacies. We covalently conjugated polyethylene glycol on the surface of CK (PEG-CK) through an acid-labile ester-linkage that showed increased solubility of CK. HPLC analysis showed that the release of CK was enhanced at acidic pH 5, whereas it was dramatically decreased at physiological pH 7.4. This might enhance the efficacy of CK.
Funding
This research was fully supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries [KIPET No. 309019-3], and also by a grant from the Next-Generation BioGreen 21 Program [SSAC, Grant No. PJ00952903] of the Rural Development Administration of the Republic of Korea.
