Phenolic components from the stem of Acanthopanax koreanum and their inhibitory effects on NF-kappa B

Abstract

Two novel phenolic glucosides (1–2), as well as seven known compounds (3–9), were isolated from the stem of Acanthopanax koreanum; their chemical structures were determined by chemical and spectroscopic methods and subsequently compared with previously reported data. Their inhibition of nuclear factor kappa B (NF-κB) was measured in human embryonic kidney (293T) cells by using an NF-κB luciferase assay.

Key words:

• Acanthopanax koreanum
• Araliaceae
• NF-kappa B

Funding

This work was financially supported by the Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology [2009-0093815] of the Republic of Korea.